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Updated: Jul 10, 2026

Investigating the Spreading and Toxicity of Prion-like Proteins Using the Metazoan Model Organism C. elegans
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Published on: January 8, 2015

在转基因小鼠中,原诱导的粉样性心脏病具有高的血液传染性

Matthew J Trifilo1, Toshitaka Yajima, Yusu Gu

  • 1Viral-Immunobiology Laboratory, Departments of Molecular and Integrative Neurosciences and Infectology, Scripps Research Institute, La Jolla, CA 92037, USA.

Science (New York, N.Y.)
|July 11, 2006
PubMed
概括

缺乏子蛋白的转基因小鼠表现出神经外抓伤病,血液中的高子传染性和粉样蛋白沉积导致心脏病.

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...