与Helicobacter pylori相关的胃炎和初级B细胞胃淋巴瘤
A C Wotherspoon1, C Ortiz-Hidalgo, M R Falzon
1Department of Histopathology, University College and Middlesex School of Medicine, London, UK.
Lancet (London, England)
|November 9, 1991
概括
杆菌感染可以导致获得的胃粘膜相关淋巴组织 (MALT). 这种获得的MALT是胃MALT淋巴瘤 (一种常见的胃癌) 的前体.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 正常的胃粘膜缺乏淋巴组织,但初级胃淋巴瘤往往模仿粘膜相关的淋巴组织 (MALT).
- 胃淋巴组织是获得的,通常是对Helicobacter pylori感染的反应.
- 杆菌感染与胃MALT淋巴瘤的发展密切相关.
研究的目的:
- 为了研究Helicobacter pylori感染和胃淋巴状组织的获取之间的关系.
- 为了确定胃MALT淋巴瘤患者中Helicobacter pylori感染的患病率.
- 确定所获得的胃MALT在胃MALT淋巴瘤的发病过程中的作用.
主要方法:
- 从450名患有H. pylori相关性胃炎的患者的胃活检的组织病理学检查.
- 识别粘膜淋巴卵泡和B淋巴细胞透表皮.
- 对110例胃MALT淋巴瘤的H. pylori感染状况的分析.
主要成果:
- 在450名患有H. pylori胃炎的患者中,125名 (27.8%) 显示有粘膜淋巴卵泡.
- 8名患者表现出B淋巴细胞透表皮,这是一个特征性的MALT特征.
- 在110例胃MALT淋巴瘤病例中有101例 (92%) 检测到Helicobacter pylori感染.
结论:
- 胃MALT是在对Helicobacter pylori感染的反应中获得的.
- 获得的胃MALT是胃MALT淋巴瘤发展的关键背景.
- 消灭H. pylori可能是预防胃MALT淋巴瘤的潜在策略.
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