非上腺,非胆固醇神经系统和夜间呼吸道口径在喘患者和正常患者中
T W Mackay1, M F Fitzpatrick, N J Douglas
1Department of Medicine, City Hospital, Edinburgh, UK.
Lancet (London, England)
|November 23, 1991
概括
像咳和喘息这样的夜间喘症状可能源于早上减少的非上腺,非胆固醇 (NANC) 神经功能. 这项研究研究了NANC系统的变异,揭示了与夜间支气管收缩的潜在联系.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 神经免疫学 神经免疫学
- 肺部生理学 肺部生理学
背景情况:
- 夜间喘症状,包括咳和喘息,在喘患者中很常见.
- 仅仅增加的副交感音调并不能完全解释夜间支气管收缩.
研究的目的:
- 为了研究非上腺,非胆上腺 (NANC) 神经通路透支气管平滑肌的功能在一夜之间发生的变化.
- 为了确定早晨NANC系统的抑制是否有助于夜间支气管收缩.
主要方法:
- 通过比较素 (一种NANC刺激剂) 的支气管扩展作用,在0400小时和1600小时评估NANC功能.
- 试验对象包括12名正常人和12名轻度喘患者,经过表交和β-上腺体阻塞后进行了测试.
- 支气管扩展效应被测量为振荡阻力 (Ros) 的变化;研究设计是随机的,双盲的.
主要成果:
- 对素的反应中的支气管扩张在1600小时显著增加,相比于0400小时,无论是正常人还是喘患者.
- 在正常人群中,Ros在16:00小时下降了9%,而在0400小时下降了-2% (p < 0.001).
- 喘患者在16:00小时Ros下降1%,而在0400小时Ros下降7% (p = 0.001).
结论:
- 这些发现表明,NANC神经功能在清晨早些时候减少.
- 这种抑制NANC功能可能是导致喘中观察到的夜间支气管收缩的一个因素.
- 对NANC系统调制的进一步研究可能为夜间喘控制提供新的治疗策略.
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