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鼠T淋巴细胞CD2抗原1域的结构

P C Driscoll¹, J G Cyster, I D Campbell

¹Department of Biochemistry, University of Oxford, UK.

|October 24, 1991

概括

这是CD2抗原.

科学领域:

免疫学和结构生物学.
研究细胞表面受体的结构和功能.

背景情况:

CD2抗原对T-淋巴细胞相互作用至关重要,通过其第一个域 (域1) 调解粘附.
对于CD2域1的结构存在相互矛盾的模型:免疫球蛋白 (Ig) 折叠与交替的α螺旋和β链.
CD2域1作为免疫球蛋白超级家族 (IgSF) 基于序列的分配的关键测试.

研究的目的:

为了解决CD2域的结构模两可 1.
为了验证IgSF蛋白质结构的基于序列的预测.

主要方法:

在大肠杆菌中表达大鼠CD2域1的表达.
使用NMR光谱测定低分辨率溶液结构.

主要成果:

通过NMR确定了CD2域1的低分辨率结构.
这些结构数据为评估相互冲突的结构模型提供了基础.

结论:

CD2域1的确定的结构为其折叠提供了关键的见解.
这项研究促进了对CD2在T细胞粘附和IgSF结构分配中的作用的理解.

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