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血小板大小对心肌梗塞后的结果的影响
J F Martin1, P M Bath, M L Burr
1Department of Medicine, King's College School of Medicine and Dentistry, London, UK.
Lancet (London, England)
|December 7, 1991
概括
较大的平均血小板体积 (MPV),衡量血小板大小,与心脏病发作后死亡和心脏病发作复发风险的增加有关. 血小板计数没有显示这种关联,这表明MPV是一个独立的风险因素.
科学领域:
- 心脏病学 心脏病学
- 血液学 血液学 血液学
背景情况:
- 血小板特征影响缺血性心脏病.
- 血小板大小/计数与心肌梗塞 (MI) 后的结果之间的关联尚未完全理解.
研究的目的:
- 为了调查平均血小板体积 (MPV) 和血小板计数与死亡和心脏复发之间的关系,以MI指数.
主要方法:
- 在心脏病发作6个月后,对1716名男性进行了MPV和血小板计数测量.
- 结果 (死亡,复发性缺血事件) 在两年内进行了评估.
主要成果:
- 较高的MPV与致命或非致命性缺血事件的风险增加显著相关 (p < 0.001).
- 死亡的男性的MPV比幸存者大得多 (p < 0.001).
- 两组之间没有观察到血小板计数的显著差异.
结论:
- MPV是复发性心肌梗塞的一个独立风险因素.
- MPV,而不是血小板计数,预测了心脏病发作后的不良结果.
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