在实验性内毒性血症期间产生互白素-1受体对手
E V Granowitz1, A A Santos, D D Poutsiaka
1Department of Medicine, New England Medical Centre, Tufts University School of Medicine, Boston, Massachusetts 02111.
Lancet (London, England)
|December 7, 1991
概括
在人类志愿者中,内毒素注射引发了强烈的自然反应,产生了明显更多的互乐金-1受体对手 (IL-1ra) 比互乐金-1 (IL-1). 这表明身体主要使用抗剂来对抗内毒素的影响.
科学领域:
- 免疫学 免疫学 免疫学
- 败血症的发病原因
- 人体生理学 人体生理学
背景情况:
- 互白素-1 (IL-1) 在败血症的发展中起作用.
- 介素-1受体对抗剂 (IL-1ra) 自然抑制IL-1的活性.
- 在没有激活细胞受体的情况下,IL-1ra与IL-1竞争细胞受体.
研究的目的:
- 为了研究人体对内毒素的自然反应.
- 在内毒素注射后量化IL-1和IL-1ra的血水平.
- 为了比较IL-1激动剂与对抗剂在对内毒素的反应中的产生.
主要方法:
- 在使用大肠杆菌内毒素的9名健康志愿者中诱导了内毒症.
- 血IL-1和IL-1ra度通过放射性免疫检测测测量了24小时.
- 一个由4名志愿者组成的对照组接受了盐水注射.
主要成果:
- 血IL-1ra度的峰值大约是IL-1β度的100倍.
- 在盐水对照组中没有发现IL-1或IL-1ra的可检测水平.
- 内毒素挑战导致IL-1ra产量的明显增加.
结论:
- 人类对内毒素的首要自然免疫反应涉及对抗剂 (IL-1ra) 的产生比对抗剂 (IL-1) 的产生更大.
- 这表明存在一种保护机制,即身体限制了由IL-1调解的炎症反应.
- 这些发现凸显了IL-1ra在调节内毒素诱导的炎症中的关键作用.
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