成年人体重变化和绝经后乳腺癌的风险
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Updated: Jul 20, 2026

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Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
Published on: October 16, 2010
A Heather Eliassen1, Graham A Colditz, Bernard Rosner
1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass 02115, USA. heather.eliassen@channing.harvard.edu
JAMA
|July 13, 2006
概括
自成年和更年期以来的体重增加增加了绝经后妇女的乳腺癌风险. 绝经后保持或减肥可能会降低乳腺癌的风险,特别是对于荷尔蒙非使用者.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 内生激素是乳腺癌的主要驱动因素.
- 肥胖会影响荷尔蒙水平,特别是在绝经后的女性中,这可能是乳腺癌的可修改风险因素.
研究的目的:
- 调查成年人体重变化 (18岁和绝经以来) 与绝经后妇女乳腺癌风险之间的关联.
主要方法:
- 使用护士健康研究数据 (87,143名绝经后妇女) 的前性队列研究.
- 自18岁以来和更年期以来长期随访期间 (长达26年) 评估体重变化.
- 监测侵袭性乳腺癌的发病率作为主要结局.
主要成果:
- 观察到乳腺癌风险显著增加,体重增加显著 (自18岁以来≥25.0公斤;自更年期以来≥10.0公斤).
- 绝经后体重增加与从未使用过绝经后荷尔蒙的女性的乳腺癌风险有较强的关联.
- 减肥 (更年期以来≥10.0公斤) 与风险降低有关,特别是在荷尔蒙非使用者中.
结论:
- 成年人体重增加,特别是在绝经后,在绝经后的妇女中增加乳腺癌的风险.
- 绝经后减肥与降低乳腺癌风险有关.
- 建议在更年期期间保持或达到健康体重,以减少乳腺癌风险.
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