压力和β阻塞对血小板功能的影响
P Hjemdahl1, P T Larsson, N H Wallén
1Department of Clinical Pharmacology, Karolinska Hospital, Stockholm, Sweden.
Circulation
|December 1, 1991
概括
压力会激活血小板,而β阻断可能会降低血小板功能. 需要进一步的研究来了解这些对人类血栓形成和动脉样硬化的影响.
科学领域:
- 心血管生理学心血管生理学
- 血液静止和血栓形成
背景情况:
- 血小板功能评估面临着方法上的挑战.
- 交腺激活可以在体外不一致地改变血小板聚合能力.
- 在压力期间的活体血小板激活更一致地观察到.
研究的目的:
- 审查交腺激活和β阻塞对血小板功能的影响.
- 突出了改善人体血小板功能研究的必要性.
- 探索对血栓形成和动脉样硬化的影响.
主要方法:
- 在体外和体内血小板功能评估技术的审查.
- 对交腺激活 (压力,上腺素) 和血小板反应的研究分析.
- 审查关于β阻塞对血小板功能影响的研究.
主要成果:
- 在体内测量结果始终显示在压力期间血小板激活.
- 循环中的上腺素水平不能完全解释压力诱导的预聚合效应.
- 在体内,β阻塞对血小板功能的影响是相互矛盾的,一些研究表明减弱.
结论:
- 压力通常会增强血小板功能,而β阻塞可能会降低血小板功能.
- 在β阻塞期间了解体内血小板反应对于心血管疾病至关重要.
- 方法上的进步对于准确评估人类血小板功能至关重要.
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