压力生活事件和格雷夫斯病
B Winsa1, H O Adami, R Bergström
1Department of Internal Medicine, Uppsala University, Sweden.
Lancet (London, England)
|December 14, 1991
概括
压力较大的生活事件和家族甲状腺疾病病史是发展Graves的重要风险因素.
科学领域:
- 内分泌学 在内分泌学.
- 流行病学 流行病学
- 心理神经免疫学 心理神经免疫学
背景情况:
- 由于先前研究的局限性,压力较大的生活事件与格雷夫斯病发病之间的联系仍在争论中.
- 以前的研究缺乏足够的控制和诊断特异性,导致不确定的发现.
研究的目的:
- 调查生活事件,遗传,社会支持和发展格雷夫斯病的风险之间的联系.
- 进行基于人口的病例控制研究,以澄清潜在的风险因素.
主要方法:
- 一个基于人口的病例控制研究在一个大约100万居民的地区进行.
- 208名新诊断的格雷夫斯病患者和372名匹配的对照患者填写了有关各种生活方式和家庭因素的邮寄问卷.
- 数据分析包括多变量分析,以调整混因素.
主要成果:
- 患者在诊断前一年报告了显著更多的负面生活事件 (OR 6.3).
- 甲状腺疾病的家族病史,特别是在第一和二度亲属中,增加了Graves病的风险 (OR 3.6).
- 离婚 (OR 1.8) 和较低的酒精消费 (OR 0.4) 也与风险增加有关.
结论:
- 负面的生活事件和遗传性倾向被确定为格雷夫斯病的显著风险因素.
- 这些发现支持心理社会和遗传因素在格雷夫斯病病因学中的作用.
- 需要进一步的研究来阐明潜在的机制.
相关概念视频
Stress: General Loading Conditions
To grasp the intricacy of real-world conditions where multiple loads are applied simultaneously to a structure, one might visualize a section passing through a specific point within a body, aligned parallel to the xy plane. This section is subjected to various forces, including original loads, normal forces, and shearing forces.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes.
The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes.
General State of Stress
The general state of stress within a material can be accurately depicted using a stress tensor. This tensor encapsulates the internal forces distributed within a material subjected to external forces or deformations.
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
Introduction to Stress and Lifestyle
Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...
Types of Stressors
A stressor is any event, condition, or stimulus that triggers stress and causes a physical or psychological response in the body. Stressors can be categorized into three main types: catastrophes; significant life changes; and daily hassles, including social stress. Each can be detrimental to physical and mental well-being.
Catastrophes
Catastrophes refer to large-scale, unpredictable events that create overwhelming stress and a sense of threat. Examples include natural disasters like...
Catastrophes
Catastrophes refer to large-scale, unpredictable events that create overwhelming stress and a sense of threat. Examples include natural disasters like...
Lazarus's Cognitive Appraisal Theory
Cognitive psychologist Richard Lazarus proposed the cognitive-mediational theory of emotions, which emphasizes how individuals' assessments of stressors significantly affect their experience of stress. According to Lazarus, the stress response is determined by a two-step appraisal process: primary appraisal and secondary appraisal. These cognitive appraisals help individuals evaluate the potential impact of a stressor and determine the adequacy of their coping resources.
Primary Appraisal:...
Primary Appraisal:...
Stress and Mental Health
Chronic stress profoundly affects mental health, significantly influencing mood, behavior, and overall quality of life. Research closely links chronic stress with mental health conditions such as depression, anxiety, and substance use disorders. Ongoing exposure to stress can lead to physiological and psychological changes, initiating a cycle of emotional distress and maladaptive coping mechanisms.
Individuals with depression often experience challenges in both their personal and professional...
Individuals with depression often experience challenges in both their personal and professional...


