垂直倾斜时的血内甲蛋白:与正静性低血压的相关性?
H Kaufmann1, E Oribe, J A Oliver
1Department of Neurology, Mount Sinai School of Medicine, New York 10029.
Lancet (London, England)
|December 21, 1991
概括
巴罗受体反射激活刺激内甲蛋白释放到血中,可能来自神经. 缺陷的内啡林释放可能会导致原发性自主性衰竭中静止性低血压.
科学领域:
- 心血管生理学心血管生理学
- 内分泌学 在内分泌学.
- 神经科学是一个神经科学.
背景情况:
- 血内衣素度随着直立姿势而上升,随着体积膨胀而下降.
- 巴罗受体反射在调节血压和液体平衡方面发挥着至关重要的作用.
研究的目的:
- 为了调查巴罗受体反射激活是否会触发内甲蛋白释放到血中.
- 检查在姿势变化期间巴罗受体功能和内甲林/血管压素水平之间的关系.
主要方法:
- 在被动垂直倾斜时评估血内衣素和血管压素度.
- 研究了四组:正常患者,自主功能衰竭患者,血管昏患者和无味糖尿病患者.
主要成果:
- 正常的受试者在垂直倾斜时表现出内甲素和血管压素的增加.
- 患有自主性衰竭的患者尽管血压下降,但内甲素水平没有上升.
- 血管综合症患者表现出内甲蛋白和血管压素的增加,而糖尿病无味症患者没有表现出内甲蛋白的变化.
结论:
- 巴罗受体反射激活似乎会诱导内甲蛋白释放,可能来自神经.
- 缺陷的内甲蛋白释放可能是初级自主性衰竭中出现的正静性低血压的一个因素.
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