评论"正在进行的ASPM的适应性进化,这是人类大脑大小的决定因素"和"微头,一个调节大脑大小的基因,在人类中继续适应性进化"
Mathias Currat1, Laurent Excoffier, Wayne Maddison
1Department of Zoology, University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
概括
结合人口增长和空间结构的人类进化模型解释了大脑基因模式,而没有持续的选择. 这些发现挑战了关于ASPM和小头基因的先前结论.
科学领域:
- 人类进化遗传学人类进化遗传学
- 人口遗传学 人口遗传学
- 分子人类学分子人类学.
背景情况:
- 之前的研究检查了人类大脑发育基因,ASPM和小头.
- 这些研究表明,这些基因在现代人类中存在持续的积极选择.
研究的目的:
- 研究人类大脑发育基因中观察到的遗传模式的替代解释.
- 测试人口历史模型是否可以解释遗传数据而不调用选择.
主要方法:
- 利用人类人口历史的计算建模.
- 纳入人口增长和空间结构的因素.
- 分析了现代人类群体的序列数据.
主要成果:
- 包括人口增长和空间结构在内的模型成功地复制了ASPM和小头基因区域的观察模式.
- 这些模式可以单独通过人口因素来解释,而不需要持续的选择.
结论:
- 在人类大脑发育基因中观察到的遗传模式不需要持续的选择.
- 人口历史,包括人口增长和空间结构,为这些模式提供了足够的解释.
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