从酒精中通过介导的基基转移合成二次胺
Balasubramanian Ramanathan1, Aaron L Odom
1Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, USA.
Journal of the American Chemical Society
|July 20, 2006
概括
胺复合物促进选择性基从酒精转移到氨基,通过拟议的循环添加机制形成二次基氨基. 这种方法还可以从同质醇中合成复杂的螺旋环胺.
科学领域:
- 有机金属化学 有机金属化学
- 合成有机化学 合成有机化学
- 催化剂是一种催化剂.
背景情况:
- 胺是有机合成中的多功能试剂.
- 基转移反应对于碳-碳和碳-异原子键的形成至关重要.
- 开发选择性和高效的合成方法是化学的一个关键目标.
研究的目的:
- 为了研究四甲基 (((二甲基胺) (Ti ((NMe2) 4) 与醇和初级氨基的反应.
- 探索基转移和基转移的机制.
- 检查该方法与同质醇用于复杂分子合成的应用.
主要方法:
- Ti(NMe2) 4 与各种醇和初级胺基的反应.
- 对反应产物的分析以确定选择性和立体化学.
- 涉及替代物效应的机制研究,以阐明反应通路.
- 研究与同质醇反应的研究.
主要成果:
- 通过从酒精转移到氨基的基转移选择性形成二次基胺.
- 在转移过程中观察选择性基转移.
- 基于替代效应的 [2 + 2]/逆向- [2 + 2] - 循环加法机制的定理.
- 使用同质醇的1-aza-spiro[5.5]undecane的成功合成.
结论:
- Ti(NMe2) 4 是一种有效的试剂,用于选择性基转移到氨基.
- 反应通过拟议的循环加法机制进行,证明了基转化.
- 该方法可以扩展到同质醇,用于合成复杂的螺旋环结构.
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