偏头痛和女性心血管疾病的风险
Tobias Kurth1, J Michael Gaziano, Nancy R Cook
1Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass 02215-1204, USA. tkurth@rics.bwh.harvard.edu
JAMA
|July 20, 2006
概括
偏头痛与光环显著增加女性心血管疾病的风险,包括心脏病发作和中风. 没有光环的偏头痛似乎不会增加这些风险.
科学领域:
- 心脏病学 心脏病学
- 神经学 神经学
- 流行病学 流行病学
背景情况:
- 带有光环的偏头痛与不良的心血管风险因素和前血栓状况有关.
- 虽然与缺血性中风相关,但其与更广泛的心血管疾病 (CVD) 和冠状动脉事件的联系尚未完全理解.
研究的目的:
- 调查偏头痛,有或没有光环之间的关联,以及随后的整体和特定心血管疾病的风险.
- 为了澄清不同类型的偏头痛和女性心血管结果之间的关系.
主要方法:
- 一项前性队列研究,涉及来自妇女健康研究的27,840名45岁以上的美国女性.
- 随访数据平均收集了10年,评估了主要心血管疾病事件,缺血性中风,心肌梗塞,冠状动脉再血管化和心痛.
主要成果:
- 有着光环的活跃偏头痛的女性显著增加了主要心血管疾病的风险 (HR 2.15),缺血性中风 (HR 1.91),心肌梗塞 (HR 2.08) 和冠状动脉再血管 (HR 1.74).
- 每年每1万名女性中,额外的18个主要心血管疾病事件被归因于带有光环的偏头痛.
- 在没有光环的活跃偏头痛的女性中,没有观察到血管事件风险增加.
结论:
- 带有光环的活跃偏头痛与重大心血管事件的风险大幅增加有关,包括心肌梗塞和缺血性中风.
- 这些发现强调了在评估心血管风险方面考虑偏头痛患者的光环状况的重要性.
- 在这个队列中,没有光环的偏头痛与心血管疾病风险增加没有显著的关联.
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