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Updated: Jun 14, 2026

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin
07:56

Modified Yeast-Two-Hybrid System to Identify Proteins Interacting with the Growth Factor Progranulin

Published on: January 17, 2012

进子素的零突变会导致与染色体17q21相关的泛素阳性前性痴呆症

Marc Cruts1, Ilse Gijselinck, Julie van der Zee

  • 1Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, Universiteitsplein 1, BE-2610 Antwerpen, Belgium.

Nature
|July 25, 2006
PubMed
概括

进子素 (PGRN) 基因的突变通过降低PGRN水平,导致神经退行导致前性痴呆症 (FTDU-17) . 在家族性FTD中,PGRN突变比MAPT突变更常见.

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