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相关概念视频

Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
Huntington Disease l: Introduction01:21

Huntington Disease l: Introduction

Huntington disease or HD is a progressive, fatal neurodegenerative disorder inherited in an autosomal dominant pattern.PathophysiologyIt is caused by expansion of the CAG trinucleotide repeat in the HTT gene on chromosome 4 (4p16.3), producing an abnormal huntingtin protein with an expanded polyglutamine tract. This misfolded protein disrupts cellular function, leading to neuronal death. Normal alleles have ≤26 repeats, 27–35 are intermediate (risk of expansion), 36–39 show reduced penetrance,...

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相关实验视频

Updated: Jul 6, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

阿尔茨海默病的疾病阿尔茨海默病的疾病.

Kaj Blennow1, Mony J de Leon, Henrik Zetterberg

  • 1Clinical Neurochemistry Laboratory, Department of Neuroscience and Physiology, Sahlgren's University Hospital, Mölndal, Sweden. kaj.blennow@neuro.gu.se

Lancet (London, England)
|August 1, 2006
PubMed
概括

阿尔茨海默病是一种常见的痴呆症,涉及粉样β斑块和团. 它的复杂原因,特别是零星形式,涉及衰老,遗传和环境因素,需要进一步研究有效的治疗方法.

科学领域:

  • 神经学 神经学
  • 分子生物学分子生物学
  • 遗传学 是一个遗传学.

背景情况:

  • 阿尔茨海默病 (AD) 是导致痴呆的主要原因.
  • 关键的病理特征包括粉样β (Abeta) 斑块和高酸化团.
  • 了解AD的发病因子正在进步,揭示了显著的复杂性.

研究的目的:

  • 审查阿尔茨海默氏病的流行病学,遗传学,病变发生,诊断和治疗.
  • 突出阿尔茨海默病研究的最新发展和持续的争议.
  • 区分家族和零星形式的阿尔茨海默病.

主要方法:

  • 对有关阿尔茨海默氏病的现有文献的审查.
  • 分子病原学的分析,包括Abeta和tau.
  • 对零星AD的遗传和环境风险因素的检查.

主要成果:

  • 家族性阿尔茨海默病是罕见的,早期发病,与影响阿贝塔代谢的APP和 presenilin基因突变有关.
  • 散发性AD很常见,原因不明,归因于衰老,遗传和环境相互作用.
  • 零星AD的异质性使理解和治疗开发复杂化.

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Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
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Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
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Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

相关实验视频

Last Updated: Jul 6, 2026

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies
15:48

ALS - Motor Neuron Disease: Mechanism and Development of New Therapies

Published on: July 29, 2007

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis
06:33

Genetic Analysis of Hereditary Transthyretin Ala97Ser Related Amyloidosis

Published on: June 9, 2018

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation
07:17

Wild-type Blocking PCR Combined with Sanger Sequencing for Detection of Low-frequency Somatic Mutation

Published on: August 23, 2024

结论:

  • 阿尔茨海默病的发病过程复杂,涉及遗传和环境因素.
  • 进一步的研究对于揭示散发性阿尔茨海默病的原因和开发向治疗至关重要.
  • 对AD的全面理解,从分子机制到风险因素,对于临床进展至关重要.