证据表明,在人类心室动中存在多种机制
Martyn P Nash1, Ayman Mourad, Richard H Clayton
1Bioengineering Institute and Engineering Science, University of Auckland, New Zealand.
Circulation
|August 2, 2006
概括
人的早期心室动 (VF) 可以通过有组织的回流波和无组织的小波来维持. 这些机制并不相互排斥,这表明心律失常的复杂动态.
科学领域:
- 心脏电生理学 心脏电生理学
- 节律失常的机制 节律失常机制
- 医学成像和信号处理.
背景情况:
- 在人类中驱动心室动 (VF) 的精确机制仍然不完全理解.
- 现有的实验模型提出一个稳定的"母旋转器"或多个混乱的小波作为VF的潜在原因.
- 这项研究旨在调查早期VF期间人类心室内膜上心脏的电活动模式.
研究的目的:
- 在早期VF期间,在整个人心室内绘制心上电活动的地图.
- 确定"母旋转器"和多波波段假设在维持人类VF方面的相对贡献.
- 阐明VF期间不同电生理机制之间的动态相互作用.
主要方法:
- 在10名心脏手术患者中通过爆发节奏诱导VF.
- 使用256个电极 (UnEmap系统) 在1kHz的频率记录心上表皮电活动.
- 利用信号插值,对于主导频率 (DFs) 使用快速富里埃变换 (FFT),以及用于相异常和波面分析的希尔伯特变换.
主要成果:
- 早期人类的VF涉及大型,连贯的波段,间隔有无组织的波活动.
- 主导频率 (DFs) 显示了5.11 Hz的初始拦截,并随着时间的推移而增加.
- 经常观察到心上回流,通常只有很少的相异常,有时与多个小波相互作用或由单一的回流波驱动.
结论:
- 这些发现支持"母旋转器"和人类VF中的多波小波机制的共存.
- 这些机制并不相互排斥,在人心中可以同时运作.
- 人体VF表现出复杂的电生理学动态,涉及有组织和无组织的电活动.
相关概念视频
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