Search research articles

关于 JoVE

概览领导团队博客 JoVE 帮助中心

作者

出版流程编辑委员会范围与政策同行评审常见问题投稿

图书馆员

用户评价订阅访问资源图书馆顾问委员会常见问题

研究

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments 存档

教育

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual 教师资源中心教师网站

使用条款与条件

相关概念视频

Ultrasound II: Endoscopic Ultrasound and FibroScan

Ultrasound II: Endoscopic Ultrasound and FibroScan

Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序

Same author

Detergent-like Toxicity Mechanism of Amyloid Cylindrins Revealed by Cross-Link Spin Labeling Electron Spin Resonance.

Journal of the American Chemical Society·2026

Same author

N-Terminal Amine Chemistry Influences α-Synuclein Interactions with Lipid Bilayers.

Biochemistry·2026

Same author

Correction to "Detection of Mutation-Induced Conformational Changes in an Intrinsically Disordered Protein by Double Quantum Coherence Electron Spin Resonance Methodology".

Journal of the American Chemical Society·2026

Same author

Detection of Mutation-Induced Conformational Changes in an Intrinsically Disordered Protein by Double Quantum Coherence Electron Spin Resonance Methodology.

Journal of the American Chemical Society·2026

Same author

Sulfur-containing class of broad-spectrum antivirals improves influenza virus vaccine development.

Nature communications·2026

Same author

Retraction Note: Inhibition of alpha-synuclein seeded fibril formation and toxicity by herbal medicinal extracts.

BMC complementary medicine and therapies·2025

Search research articles

相关实验视频

Updated: Jul 15, 2026

The Neuromuscular Junction: Measuring Synapse Size, Fragmentation and Changes in Synaptic Protein Density Using Confocal Fluorescence Microscopy

The Neuromuscular Junction: Measuring Synapse Size, Fragmentation and Changes in Synaptic Protein Density Using Confocal Fluorescence Microscopy

Published on: December 26, 2014

从脉冲ESR测量中,光脂菌根结合的alpha-synuclein中的螺旋间距离来自脉冲ESR测量.

Peter Borbat¹, Trudy F Ramlall, Jack H Freed

¹Department of Chemistry and Biochemistry, Cornell University, Ithaca, New York 14853, USA.

Journal of the American Chemical Society

|August 3, 2006

概括

脉冲ESR光谱学揭示了帕金森病是如何发生的.

科学领域:

生物化学生物化学
结构生物学结构生物学
神经科学是一个神经科学.

背景情况:

阿尔法同核素与帕金森病有关.
蛋白质的结构在与细胞结合时发生变化.
了解这些结构变化对于帕金森病的研究至关重要.

研究的目的:

为了测量与细胞结合的α-synuclein中的分子内距离.
为了研究小细胞组成对α-synuclein结构的影响.
为了确定影响alpha-synuclein拓学的因素.

主要方法:

使用脉冲电子自旋共振 (ESR) 光谱学.
测量了分子内距离的α-synuclein.
阿尔法-同核素与洗剂和溶解脂小粒结合.

主要成果:

在α-synuclein中螺旋之间的分离取决于小细胞组成.
微粒中较长的乙基链增加了α-synuclein螺旋体的扩散.
蛋白质的拓学受到结合表面几何学的影响.

结论:

更多相关视频

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

Published on: May 30, 2015

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

相关实验视频

Last Updated: Jul 15, 2026

The Neuromuscular Junction: Measuring Synapse Size, Fragmentation and Changes in Synaptic Protein Density Using Confocal Fluorescence Microscopy

The Neuromuscular Junction: Measuring Synapse Size, Fragmentation and Changes in Synaptic Protein Density Using Confocal Fluorescence Microscopy

Published on: December 26, 2014

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

Detection of Disease-associated α-synuclein by Enhanced ELISA in the Brain of Transgenic Mice Overexpressing Human A53T Mutated α-synuclein

Published on: May 30, 2015

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

阿尔法同核素的结构具有适应性,并受到其环境的影响.
微粒几何,而不仅仅是左边区域,决定了α-synuclein的拓.
这些发现提供了对帕金森病中蛋白质错折的见解.