在治疗脱水性腹疾病时,有症状的低血症,用降低度的口服补水溶液治疗
Nur H Alam1, Mohammed Yunus, Abu S G Faruque
1Clinical Sciences Division, International Centre for Diarrhoeal Disease Research Bangladesh, Mohakhali, Dhaka, Bangladesh. nhalam@icddrb.org
JAMA
|August 3, 2006
概括
新的降低度口服补水溶液 (ORS) 对治疗腹是安全的. 与以前的配方相比,症状性低血症的发病率是最小的,并且下降了.
科学领域:
- 公共卫生 公共卫生
- 儿科 儿科 儿科
- 临床医学 临床医学
背景情况:
- 世界卫生组织和联合国儿童基金会在2002年推了降低度的口服补水溶液 (ORS).
- 建议监测新的ORS配方的安全性,特别是症状性低血症.
研究的目的:
- 为了测量症状性低血症的发病率,在患者治疗了减少度ORS.
- 为了比较低血量率与之前的ORS配方.
主要方法:
- 2002年12月至2004年1月,孟加拉国进行了第四期试验.
- 没有并发症的水性腹患者接受了降低度的ORS,并对神经症状进行监测.
- 用旧的ORS配方对上一年的达卡医院记录进行了比较.
主要成果:
- 超过53,000名患者被监测;24名患者发作或意识变化与低血症相关.
- 症状性低血的发病率在达卡为0.05%,在马特拉布为0.03%.
- 这与上一年的0.10%率相比,代表了统计学上显著的减少.
结论:
- 症状性低血症的风险与降低度ORS是最小的.
- 在ORS配方的变化没有增加低血的风险.
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