卡尔莫杜林通路和达尔文的长嘴形态的演变在达尔文的
Arhat Abzhanov1, Winston P Kuo, Christine Hartmann
1Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature
|August 4, 2006
概括
达尔文的鱼通过自然选择进化了各种各样的嘴形状. 部发育中的卡尔莫杜林 (CaM) 路径上调解释了仙人掌中长,尖的部的进化.
科学领域:
- 进化生物学 进化生物学
- 发展生物学 发展生物学
- 基因组学就是基因组学.
背景情况:
- 达尔文的飞表现出了令人惊叹的的多样性,这是适应性辐射的经典例子.
- 之前的研究探索了达尔文的鱼形态的候选基因.
- 候选基因方法存在限制,用于识别新的发育途径.
研究的目的:
- 通过全面的转录基因方法,识别涉及达尔文嘴形态的新型基因和途径.
- 为了研究卡尔莫杜林 (CaM) 在特定形状的发展中的作用.
主要方法:
- 额外的DNA微阵列分析的鼻原始的转录.
- 在现场杂交以验证基因表达模式.
- 在小胚胎中对CaM依赖途径的实验操纵.
主要成果:
- 与其他型相比,卡尔莫杜林 (CaM) 在仙人掌的长,尖的中表达更高.
- 在胚胎中,CaM依赖性通路的升级导致上的延长,模仿了仙人掌鱼的形态.
- 这一途径为形状演变提供了一种机械解释.
结论:
- 这种依赖于CaM的途径与达尔文的长嘴形态的进化有关.
- 这一途径为尺寸的独立进化提供了一个发展机制.
- 卡尔莫杜林信号传递在调节面骨发育方面发挥着重要作用.
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