阿迪波涅丁和冠心病:一个前性研究和元分析
Naveed Sattar1, Goya Wannamethee, Nadeem Sarwar
1University Department of Vascular Biochemistry, Glasgow, Scotland. nsattar@clinmed.gla.ac.uk
Circulation
|August 9, 2006
概括
阿迪波涅克水平与冠状动脉疾病 (CHD) 风险存在弱相关性. 这项前性研究和元分析发现,阿迪波涅丁与心血管疾病之间没有显著的联系,而与其与2型糖尿病的强烈联系不同.
科学领域:
- 心血管科学 心血管科学
- 代谢健康 代谢健康
- 生物标志物研究 研究生物标志物
背景情况:
- 阿迪波涅丁与冠心病 (CHD) 风险之间的关系尚未完全理解.
- 现有的研究对阿迪波内克在心血管疾病中的作用提出了相互矛盾的证据.
研究的目的:
- 为了研究循环中的阿迪波涅丁度与患心脏病的风险之间的关联.
- 在元分析中将新的前性数据与现有研究相结合.
主要方法:
- 在一个由5661名男性 (40-59岁) 组成的前性队列中进行了一项嵌套病例控制研究.
- 在589名患有心血管疾病事件的男性和1231名对照人群中测量了基线血清阿迪波涅克水平.
- 进行了对7项前性研究的元分析,包括目前的研究,以汇集心血管疾病风险估计.
主要成果:
- 阿迪波涅克丁水平与高密度胆固醇正相关,与C反应蛋白和BMI相反.
- 在心血管疾病病例和对照人群之间,没有发现中位数阿迪波内克丁水平的显著差异.
- 对1318例心血管疾病病例的元分析显示,心血管疾病的非显著几率比为0.84 (95% CI,0.70至1.01) 跨阿迪波涅克水平.
结论:
- 阿迪波内克水平与心脏病风险之间的关联似乎是中度的,与其与2型糖尿病的强烈联系形成鲜明对比.
- 需要进一步的研究,以澄清阿迪波内克在心血管疾病发病过程中的确切作用.
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