通过使用点击化学,有效地模拟合成捐赠者-接受者罗塔克桑
William R Dichtel1, Ognjen S Miljanić, Jason M Spruell
1California NanoSystems Institute and Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095, USA.
Journal of the American Chemical Society
|August 10, 2006
概括
点击化学使得捐赠者-接受者轮素的高效合成成为可能. 这种方法使用化物功能化伪和基因堵塞剂来创建具有高产量的复杂分子架构.
科学领域:
- 超分子化学 超分子化学
- 有机合成 有机合成
- 材料科学 材料科学 材料科学
背景情况:
- 复杂的分子结构的合成,如罗塔克桑,对于先进的材料至关重要.
- 铜催化亚酸循环添加 (点击化学) 为分子组装提供温和的条件和高效率.
研究的目的:
- 开发一种高效的合成策略用于使用点击化学的捐赠者-接受者罗塔克桑.
- 作为一个pi接受元件,将cyclobis (((paraquat-p-phenylene) (CBPQT4+) 和作为一个pi捐赠单位的1,5-dioxynaphthalene (DNP) 纳入.
主要方法:
- 采用线程接的方法来合成罗塔xane.
- 使用Cu-催化Huisgen 1,3-二极循环添加在有机亚酸盐和终端酸盐之间.
- 用DNP识别单元合成化物功能化的伪,并用基因功能化的止损剂对它们进行反应.
主要成果:
- 成功合成了 [2]-, [3]-和 [4] 罗塔克桑与多个捐赠者-接受者动机.
- 证明了高产量和合成协议的优秀融合.
- 展示了点击化学与复杂的分子结构和功能组的兼容性.
结论:
- 点击化学方法提供了一种高效和多功能途径,以复杂的捐赠者-接受者罗塔克桑.
- 这种方法可以精确控制分子架构,并结合特定的识别单元.
- 开发的协议具有高度的融合性,促进了多元组分罗塔xane 系统的合成.
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