概括
使用体外循环和大动脉交叉合的冠状动脉心脏手术导致左心室的细胞损伤. 这些变化表明改变膜透性是心脏手术期间的主要问题.
科学领域:
- 心血管外科心血管外科
- 细胞生物学 细胞生物学
- 生物化学 生物化学
背景情况:
- 冠状动脉心脏手术通常涉及心肺绕道和大动脉交叉紧.
- 了解这些程序对心肌的细胞影响对于患者的治疗结果至关重要.
研究的目的:
- 为了研究体外循环和大动脉交叉紧对左心室的体内化学和超结构效应.
- 为了识别心肺旁路术期间的初始细胞侮辱.
主要方法:
- 从22名绕道手术前后的患者获得左心室的钻探活检样本.
- 组织化学分析评估了酶活性 (糖氨酸脱酶,细胞氧化酶,LDH,酸化酶A,肌酸氨酸酶) 和脂水平.
- 超结构检查评估了细胞和线粒体的完整性.
主要成果:
- 组织化学分析显示,酸脱酶,细胞氧化酶和LDH活性增加,酸酶A和肌酸酸酶活性降低.
- 自由脂水平增加,表明膜完整性发生变化.
- 超结构性发现包括糖原损失,细胞内胀和线粒体损伤 (矩阵密度损失,晶状体和破坏).
结论:
- 在左心室观察到的细胞变化类似于缺血-再输液损伤.
- 这些发现表明,体外循环和大动脉交叉紧的主要后果是膜透性调节的破坏.
相关概念视频
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
Structure of Cardiac Muscles
Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
Layers of the Heart Wall
The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
Heart Valves
The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
Development of the Heart
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart tube by...
Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...


