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Updated: May 6, 2026

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顺序的质量控制检查点分组错误折叠的囊性纤维化转膜导电性调节器

J Michael Younger1, Liling Chen, Hong-Yu Ren

  • 1Department of Cell and Developmental Biology, UNC-Chapel Hill School of Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.

Cell
|August 12, 2006
PubMed
概括

囊性纤维化涉及错误折叠的CFTR Delta F508蛋白质. 新的研究揭示了RMA1和CHIP E3泛素酶顺序向这种有缺陷的蛋白质进行降解,澄清了关键的细胞质量控制途径.

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