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相关概念视频

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
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相关实验视频

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Studying the Integration of Adult-born Neurons
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Studying the Integration of Adult-born Neurons

Published on: March 25, 2011

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通过NMDA受体介导,细胞特异的新神经元在成年牙状转中集成.

Ayumu Tashiro1, Vladislav M Sandler, Nicolas Toni

  • 1Laboratory of Genetics, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Nature
|August 15, 2006
PubMed
概括

大脑中的新神经元.

科学领域:

  • 神经科学是一个神经科学.
  • 神经新生是神经发生的过程.
  • 学习和记忆的学习和记忆

背景情况:

  • 成年人的神经发生发生在牙状,有助于学习和记忆.
  • 新神经元的存活是经验依赖的,这表明它在信息存储中的作用.
  • 新神经元生存的信息特异性是一个关键的,但尚未被证明的假设.

研究的目的:

  • 为了研究新神经元的存活是否受到细胞特异性的输入活动的调节.
  • 确定突触活动在新神经元生存中的作用.
  • 测试新神经元生存是特定信息的假设.

主要方法:

  • 在小鼠中开发了一种逆转录病毒介导的单细胞基因淘汰技术.
  • 专注于NMDA型谷氨酸受体在神经元生存中的作用.
  • 在神经元出生后不久的关键时期检查了生存率.

主要成果:

  • 新神经元的存活率由它们自己的NMDA型谷氨酸受体竞争性地调节.
  • 生存依赖于细胞特异性的输入活动.
  • 这种调节发生在出生后的关键时期.

结论:

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Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
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  • 新神经元的存活和电路的形成依赖于输入和细胞特异性.
  • 由新的神经元形成的电路可能编码与最近的输入活动相关的信息.
  • 这种特定于信息的机制凸显了成人神经发生在学习和记忆中的独特作用.