在皮层发育过程中表达的RNA基因在人类中迅速演变
Katherine S Pollard1, Sofie R Salama, Nelle Lambert
1Center for Biomolecular Science & Engineering, Department of Molecular, Cell & Developmental Biology, University of California, Santa Cruz, California 95064, USA.
研究人员发现了一种新型RNA基因,HAR1F,对人类大脑发育至关重要. 这种基因在妊娠早期的Cajal-Retzius神经元中发现,对于形成人类皮质结构至关重要.
科学领域:
- 神经科学是一个神经科学.
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
背景情况:
- 人类特有的大脑进化机制尚不清楚.
- 与黑猩猩的比较基因组学为遗传和表型变化提供了洞察力.
- 人类基因组的进化加速突出显示了快速变化的区域.
研究的目的:
- 识别和描述对人类大脑进化有贡献的新型遗传元素.
- 研究人类加速区域 (HARs) 在皮质发育中的作用.
主要方法:
- 全基因组分析以排名进化加速的区域.
- 鉴定和描述HAR1区域作为一种新型RNA基因 (HAR1F).
- 在人类新皮质发育中的HAR1F表达模式的分析.
主要成果:
- 最加速的区域,HAR1,对应于一种新的RNA基因,HAR1F.
- 在关键的人类新皮质发育期间 (7-19个妊娠周),HAR1F在Cajal-Retzius神经元中特别表达.
- 哈尔1F与里林共同表达,里林是皮质层形成的关键因素.
结论:
- HAR1F是人类特定大脑特征的重要贡献者.
- 在皮层神经元的规范和迁移中,HAR1F起着至关重要的作用.
- 包括HAR1F在内的HARs代表了理解人类独特生物学的有希望的候选人.
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