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Updated: Jul 12, 2026

SDS-PAGE/Immunoblot Detection of Aβ Multimers in Human Cortical Tissue Homogenates using Antigen-Epitope Retrieval
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证据表明,阿尔茨海默病中的β-粉样蛋白不是通过正常处理获得的

S S Sisodia1, E H Koo, K Beyreuther

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2181.

Science (New York, N.Y.)
|April 27, 1990
PubMed
概括

阿尔茨海默病涉及β-粉样质斑块.阿尔茨海默病包括β-粉样质斑块. 粉样蛋白前体蛋白 (APP) 的改变处理可能导致完整的β-粉样蛋白的释放,形成这些有毒斑块.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
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