Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Murine Nasal Lavage Fluid Collection without Blood Contamination05:12

Murine Nasal Lavage Fluid Collection without Blood Contamination

1.7K
The present protocol describes a novel method for avoiding blood contamination in murine nasal lavage fluid (NLF). Since this method ensures the NLF collection without blood contamination, it allows for more accurate detections of immunological components and various respiratory...
1.7K
Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

1.1K
OSTSS leads to pooled inflammatory mediators in the tear film, causing symptoms like epiphora and discomfort. Here, we present a case where therapeutic nasolacrimal lavage every 2 months resolved epiphora and itchiness, suggesting its efficacy as a therapeutic intervention for OSTSS. Additionally, we report subjective improvements in symptoms in 3 additional...
1.1K
Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment04:35

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

880
Saline nasal lavage can be used to sample the canine nasal immune microenvironment. Because the approach is relatively non-invasive and does not disrupt the nasal tissues, it can be performed serially. Cells and proteins collected from the nasal lavage technique can be processed for various laboratory analyses.
880
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

2.9K
A protocol for conducting a challenge in an allergen exposure chamber (AEC) facility is presented. AECs have proven to be safe and effective tools for the induction of allergic symptoms or as an endpoint in the efficacy testing of allergen immunotherapy due to their ability to maintain stable particle concentrations and environmental...
2.9K
Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

12.0K
Batrachochytrium dendrobatidis infection in amphibians can be eliminated using a reduced concentration (0.0025%) and shorter duration (five minute baths for six days) of itraconazole than is generally used. Less mortality and fewer negative side effects were observed using this modified treatment...
12.0K
Intranasal Administration of CNS Therapeutics to Awake Mice07:15

Intranasal Administration of CNS Therapeutics to Awake Mice

61.4K
A method to intranasally administer drugs to awake mice for the purpose of targeting the brain is described. This method allows for repeat dosing over long periods using intranasal administration of drug without anesthesia, and nose-to-brain delivery with minimal systemic...
61.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

NLRP6 drives cutaneous wound healing during Staphylococcus aureus infection in mice.

Life sciences·2026
Same author

cGAS-STING dependent type I IFN reduces Leptospira interrogans renal colonization in mice.

PLoS pathogens·2026
Same author

Antimicrobial treatment ameliorates delirium-like phenotypes in a murine model of urinary tract infection.

Translational psychiatry·2025
Same author

cGAS-STING dependent type I IFN protects against <i>Leptospira interrogans</i> renal colonization in mice.

bioRxiv : the preprint server for biology·2025
Same author

Regulation of the NLRP3 inflammasome by autophagy and mitophagy.

Immunological reviews·2024
Same author

Gasdermin D and Gasdermin E Are Dispensable for Silica-Mediated IL-1β Secretion from Mouse Macrophages.

ImmunoHorizons·2024

相关实验视频

Updated: Jan 7, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

1.1K

炎症体:免疫应对细胞应激反应的第一线.

Yasunori Ogura1, Fayyaz S Sutterwala, Richard A Flavell

  • 1Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.

Cell
|August 23, 2006
PubMed
概括

NALP3-炎症酶组蛋白质复合体激活caspase-1,促进炎症性细胞因子的释放. 本综述探讨了在炎症期间调节caspase-1活动的新见解.

科学领域:

  • 免疫学 免疫学 免疫学
  • 分子生物学分子生物学
  • 炎症研究 炎症研究

背景情况:

  • NALP3-炎症酶是一种关键的蛋白质复合体,参与天生的免疫力.
  • 它调解了酶-1的激活,酶-1是炎症途径中的关键酶.
  • 激活NALP3-炎症酶会导致促炎细胞因子的释放.

研究的目的:

  • 讨论了解NALP3-炎症酶调节的最新进展.
  • 探索控制炎症反应中的卡斯巴酶-1活性的机制.
  • 突出内源性危险信号和病原体相关化合物在炎症酶激活中的作用.

主要方法:

  • 对最近有关炎症生物学的研究进行文献综述.
  • 对研究caspase-1激活途径的研究进行分析.
  • 讨论参与NALP3-炎症酶调节的信号分子和细胞组件.

主要成果:

  • NALP3-炎症酶激活是由各种刺激触发的,包括危险信号和病原体成分.
  • 卡斯巴-1活性受到严格调节,以控制炎症性细胞因子的产生.
  • 新的洞察力揭示了复杂的调节网络,控制着炎症细胞的功能.

更多相关视频

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
04:35

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

880
Intranasal Administration of CNS Therapeutics to Awake Mice
07:15

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

61.4K

相关实验视频

Last Updated: Jan 7, 2026

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome
03:40

Nasolacrimal Lavage as a Treatment for Ocular Surface Toxic Soup Syndrome

Published on: April 25, 2025

1.1K
Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment
04:35

Saline Lavage for Sampling of the Canine Nasal Immune Microenvironment

Published on: December 27, 2024

880
Intranasal Administration of CNS Therapeutics to Awake Mice
07:15

Intranasal Administration of CNS Therapeutics to Awake Mice

Published on: April 8, 2013

61.4K

结论:

  • 了解NALP3-炎症酶调节对于开发抗炎疗法至关重要.
  • 需要进一步的研究,以充分阐明控制卡斯巴-1的复杂机制.
  • NALP3炎症酶体是调节炎症疾病的重要目标.