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Purification of Ubiquitinated p53 Proteins from Mammalian Cells
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对一个与MDM2复合的8-mer p53类型的晶体分析

Kaori Sakurai1, Carsten Schubert, Daniel Kahne

  • 1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.

Journal of the American Chemical Society
|August 24, 2006
PubMed
概括

诺华的,一个强大的p53-MDM2抑制剂,揭示了它的结构基础. 关键残留物6 - 三和甲氨对其增强活性至关重要.

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Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...