抗生素治疗对住院阿尔茨海默症患者发烧结果的影响
K J Fabiszewski1, B Volicer, L Volicer
1Geriatric Research, Education & Clinical Center, E. N. Rogers Memorial Veterans Hospital, Bedford, Mass. 01730.
JAMA
|June 20, 1990
概括
在阿尔茨海默氏症患者中,抗生素治疗发烧并没有影响晚期病例的结果. 然而,较不严重的患者在抗生素干预后的生存率有所改善.
科学领域:
- 老年病的医生 老年病的医生
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 阿尔茨海默病 (AD) 患者经常出现发烧发作.
- 抗生素治疗对住院阿尔茨海默病患者发烧结果的影响需要澄清.
研究的目的:
- 为了前性地评估抗生素治疗与息治疗对住院阿尔茨海默病患者发烧结果的影响.
主要方法:
- 一项为期34个月的前性研究比较了抗生素组 (诊断工作和抗生素) 与息组 (仅提供舒适度).
- 使用生存分析来根据疾病严重程度比较各组之间的结果.
主要成果:
- 发烧发病率在两组中都是相似的.
- 对于严重受影响的患者群体之间没有观察到生存差异.
- 较不严重的患者在抗生素组的生存率高于息组的生存率.
结论:
- 对发烧的抗生素治疗不会改变晚期阿尔茨海默病的结果.
- 抗生素可能与患有发烧的阿尔茨海默氏症患者的生存率改善有关.
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