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布德索尼德与formoterol结合用于缓解喘恶化症的缓解疗法的效果:一项随机对照双盲研究
Klaus F Rabe1, Tito Atienza, Pál Magyar
1Department of Pulmonology, University of Leiden, Leiden, Netherlands. K.F.Rabe@lumc.nl
Lancet (London, England)
|August 29, 2006
概括
与formoterol或terbutaline相比,根据需要使用budesonide-formoterol显著减少了严重的喘恶化. 这种组合疗法增强了对维持治疗的患者的保护.
科学领域:
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
- 临床试验 临床试验
背景情况:
- 根据需要吸入皮质类固醇 (ICS) 和长效β2激动剂 (LABA) 在喘管理中的作用需要进一步澄清.
- 这项研究研究了在维持治疗的症状性喘患者的三个缓解策略.
研究的目的:
- 为了比较三种随时需要的缓解药物的疗效和安全性,在布德尼德-福莫特醇维持治疗的症状性喘患者中.
- 评估第一个严重喘恶化和其他相关结果的时间.
主要方法:
- 一项为期12个月的双盲并行组研究,涉及3394名12岁及以上的患者.
- 患者接受了布德索尼德-福莫特维护疗法以及根据需要的特布塔林,福莫特或布德索尼德-福莫特.
- 主要结局:到第一个严重恶化的时间 (住院治疗,紧急治疗或长时间的口服类固醇使用).
主要成果:
- 按需要使用的布德索尼德-福莫特与福莫特和特布他林相比,显著增加了第一个严重恶化的时间.
- 严重恶化率分别为每100个患者年中的19,29和37个,根据需要分别为布德索尼德-福莫特罗尔,福莫特罗尔和特尔布塔林.
- 喘控制日在不同组中同样有所改善;根据需要的formoterol没有显著改善症状超过terbutaline.
结论:
- 根据需要,布德尼德-福莫特能在接受维护性联合治疗的患者中提供加强的保护,防止严重的喘恶化.
- 当作为缓解剂使用时,布塞尼德-福莫特醇的两个成分都会促进这种保护作用.
- 所有测试的治疗方法都被患者容忍得很好.
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