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Updated: Jul 20, 2026

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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
轻度或中度持续性喘的药理管理
Paul M O'Byrne1, Krishnan Parameswaran
1Firestone Institute for Respiratory Health, St Joseph's Healthcare and Department of Medicine, McMaster University, Hamilton, Ontario, Canada. obyrnep@mcmaster.ca
Lancet (London, England)
|August 29, 2006
概括
定期的吸入性皮质类固醇治疗有效地管理轻度持久性喘,往往可以防止需要额外的药物. 对于中度病例,将吸入性皮质类固醇与长效β2激动剂相结合,可显著改善喘控制并减少恶化.
科学领域:
- 肺部病理学 肺部病理学
- 过敏和免疫学 过敏和免疫学
- 药理学 药理学是指药理学的学科.
背景情况:
- 由于患者与医生的接触不频繁,轻度持久性喘经常未得到充分治疗.
- 目前的治疗指南建议吸入皮质类固醇作为轻度持久性喘的主要治疗方法.
研究的目的:
- 审查支持轻度持久性喘吸入性皮质类固醇治疗的证据.
- 评估适度持续性喘的治疗策略,包括组合疗法.
- 探索耐火性喘病例的先进治疗指南.
主要方法:
- 对大型随机临床试验的研究结果的综述.
- 吸入性皮质类固醇,白血素修饰剂和组合疗法的比较分析.
- 讨论作为维持和缓解治疗的布德索尼德和福莫特醇.
- 在治疗指南中考虑在诱导的唾液中测量呼吸道炎症.
主要成果:
- 低剂量的吸入性皮质类固醇对轻度持续性喘有益,很少需要额外的药物.
- 利可托里因修饰剂的效果不如吸入性皮质类固醇.
- 吸入性皮质类固醇和长效β2激动剂的联合治疗与增加的皮质类固醇剂量相比,改善了中度持续性喘的控制.
- 作为维持和缓解治疗的布德索尼德和佛莫特醇进一步减少严重恶化.
结论:
- 大多数喘患者可以通过当前基于证据的策略来实现良好的控制.
- 在诱导的唾液中测量呼吸道炎症可以指导对不响应标准治疗的患者的治疗.
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