在转移基因工程淋巴细胞后,患者的癌症回归
Richard A Morgan1, Mark E Dudley, John R Wunderlich
1Surgery Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA.
概括
在转移性黑色素瘤患者中,表达瘤特异性受体的基因工程T细胞可以调解癌症的持久回归. 这种免疫疗法方法对晚期癌症治疗有希望.
科学领域:
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
- 基因治疗 基因治疗
背景情况:
- 收养淋巴细胞转移可以诱导癌症回归,但在产生瘤特异性T细胞方面经常面临局限性.
- 转移性黑色素瘤仍然是癌症治疗的一个重大挑战,需要新的治疗策略.
研究的目的:
- 为了设计自身的淋巴细胞,专门识别和向瘤细胞在患有转移性黑色素瘤的患者.
- 评估使用瘤特异性T细胞受体工程化的T细胞采用转移的安全性和有效性.
主要方法:
- 使用逆转录病毒编码T细胞受体,以赋予自身淋巴细胞特定的瘤识别.
- 在一个由15名转移性黑色素瘤患者组成的队列中进行这些基因工程T细胞的收养转移.
主要成果:
- 转化细胞实现了持久的移植,在输液后2个多月内超过10%的外周血液淋巴细胞.
- 一年后,在两名经历了转移性黑色素瘤病变客观回归的患者中观察到高持续水平的工程细胞.
结论:
- 基因工程T细胞对于癌症的生物治疗具有治疗潜力.
- 这种方法为克服转移性黑色素瘤采用免疫疗法的T细胞生成局限性提供了一个有希望的策略.
相关概念视频
Cancer Stem Cells and Tumor Maintenance
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Stem Cell Therapy for Tissue Regeneration
Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Bone Marrow Sampling and Transplants
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...


