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在头癌中进行过分或加速放射治疗:一个元分析
Jean Bourhis1, Jens Overgaard, Hélène Audry
1Radiation Oncology Department, Institut Gustave Roussy, Villejuif, France.
Lancet (London, England)
|September 5, 2006
概括
改变的分离放射治疗显著改善了头部和部状细胞癌患者的生存率. 与其他改变的分化方法相比,高分化提供了最大的生存益处.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
背景情况:
- 非传统的分离放射治疗在头部和部状细胞癌 (HNSCC) 存活率中的作用尚不清楚.
- 之前的试验对改变分成技术的有效性产生了不确定的结果.
研究的目的:
- 进行一项元分析,评估非传统分离放射治疗对HNSCC患者存活时间的影响.
- 为了比较高分离和加速放射治疗与传统方法的生存益处.
主要方法:
- 随机对照试验的系统综述和元分析,比较了非转移性HNSCC中常规放射治疗与高分离或加速放射治疗.
- 包括来自15项涉及6515名患者的试验的最新个体患者数据.
- 将试验分类为高分量,加快和加快与总剂量减少组.
主要成果:
- 改变的分离放射治疗显示出显著的生存益处,在5年内绝对改善3.4% (HR 0.92,p=0.003).
- 与加速放射治疗 (1.7-2%在5年) 相比,高分离放射治疗显示出更大的益处 (8%在5年).
- 在局部区域控制中观察到显著的益处 (在5年内6.4%,p<0.0001),特别是在减少局部失效方面,并且在年轻的患者 (<50岁) 中更为明显.
结论:
- 改变的分离放射治疗是一种有效的治疗方法,可以改善头部和部状细胞癌的存活率.
- 超分离成为最有益的改变放射治疗技术,提供了最大的生存优势.
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