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Updated: May 10, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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通过AMPK和GSK3的协调酸化,TSC2整合了Wnt和能量信号,以调节细胞生长

Ken Inoki1, Hongjiao Ouyang, Tianqing Zhu

  • 1Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.

Cell
|September 9, 2006
PubMed
概括

通过抑制GSK3,Wnt信号激活mTOR通路,促进细胞生长和瘤发育. 拉帕米辛可以阻止这种Wnt诱导的生长,提供潜在的癌症治疗.

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