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Updated: May 3, 2026

A RANKL-based Osteoclast Culture Assay of Mouse Bone Marrow to Investigate the Role of mTORC1 in Osteoclast Formation
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Published on: March 15, 2018

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SIN1/MIP1 保持了 rictor-mTOR 复合体的完整性,并调节了 Akt 酸化和基质特异性

Estela Jacinto1, Valeria Facchinetti, Dou Liu

  • 1Department of Physiology and Biophysics, UMDNJ-Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.

Cell
|September 12, 2006
PubMed
概括

SIN1是mTORC2的关键子单元,对于Akt Ser473酸化和细胞存活至关重要. 它的缺失会破坏TORC2的功能,但不会破坏TORC1的功能,影响特定的Akt目标,如FoxO1/3a.

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