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Using In Vitro Fluorescence Resonance Energy Transfer to Study the Dynamics Of Protein Complexes at a Millisecond Time Scale
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在DDB1-CUL4A全方位化酶机械的分子架构和组装

Stephane Angers1, Ti Li, Xianhua Yi

  • 1Howard Hughes Medical Institute, University of Washington, School of Medicine, Box 357280, Seattle, Washington 98195, USA.

Nature
|September 12, 2006
PubMed
概括

在DDB1-CUL4A-ROC1 E3泛基因结合酶使用一个独特的结构机制来招募基质. 新型WD40重复蛋白与DDB1结合,使多功能蛋白质在DNA修复和病毒感染途径中无处不在.

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