从氧乙中进行可逆烯挤出
Endre Szuromi1, Jianguo Wu, Paul R Sharp
1Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
Journal of the American Chemical Society
|September 14, 2006
概括
观察到来自氧乙的可逆烯挤出. 电爱复合物,如BF3,显著加快了这种反应,提供了新的催化途径.
科学领域:
- 有机金属化学 有机金属化学
- 催化剂是一种催化剂.
背景情况:
- 氧乙是含有氧键的有机金属化合物.
- 了解它们的反应性对于开发新的合成方法至关重要.
研究的目的:
- 为了研究从氧乙中挤出基的过程.
- 为了确定能提高这种反应速度的催化剂.
主要方法:
- 氧乙中间体的合成和表征.
- 在各种电友催化剂的存在下进行反应监测.
主要成果:
- 成功地观察到从酸中可逆的烯挤出.
- 发现电性复合物,三酸 (HOTf),银离子 (Ag+) 和三化物 (BF3) 催化了反应.
- BF3表现出了最显著的利率提升.
结论:
- 电友性激活是促进基从氧乙烯挤出基的关键.
- 这些发现为氧乙在有机合成中的新型催化应用开辟了道路.
相关概念视频
Oxidative Cleavage of Alkenes: Ozonolysis
In ozonolysis, ozone is used to cleave a carbon–carbon double bond to form aldehydes and ketones, or carboxylic acids, depending on the work-up.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.
Alcohols from Carbonyl Compounds: Reduction
Reduction is a simple strategy to convert a carbonyl group to a hydroxyl group. The three major pathways to reduce carbonyls to alcohols are catalytic hydrogenation, hydride reduction, and borane reduction.
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...
Catalytic hydrogenation is similar to the reduction of an alkene or alkyne by adding H2 across the pi bond in the presence of transition metal catalysts like Raney Ni, Pd–C, Pt, or Ru. Aldehydes and ketones can be reduced by this method, often under mild to moderate heat (25–100°C) and...
Oxidation of Alcohols
In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
The process of oxidation in a chemical reaction is observed in any of the three forms:
Ion Exchange
Ion exchange chromatography separates charged molecules from a solution by reversibly exchanging them with mobile, or 'active', ions associated with the oppositely charged stationary phase. This method can be used to separate ions, soften and deionize water, and purify solutions. The polymers comprising the ion-exchange column are high-molecular-weight and chemically stable polymers, crosslinked to be porous and essentially insoluble. They are also functionalized with either acidic or basic...
Ion-Exchange Chromatography
Ion-exchange chromatography, or IEC, is a technique for separating ions based on their affinity for the stationary phase. The stationary phase is a cross-linked polymer resin with covalently attached ionic functional groups. The functional groups can be either positively charged (cation exchangers) or negatively charged (anion exchangers). A cation exchanger consists of a polymeric anion and active cations, while an anion exchanger is a polymeric cation with active anions. The choice of...
Phase I Reactions: Oxidation of Carbon-Heteroatom and Miscellaneous Systems
Oxidative reactions are pivotal in metabolizing numerous compounds, including pharmaceutical drugs. These reactions often occur in carbon-heteroatom systems, such as carbon-nitrogen, carbon-sulfur, and carbon-oxygen.
In carbon-nitrogen systems, aliphatic and aromatic amines can undergo oxidative reactions. Secondary and tertiary amines, like those found in tricyclic antidepressants, can undergo N-dealkylation, a process that involves the oxidation of the alkyl group. In addition, oxidative...
In carbon-nitrogen systems, aliphatic and aromatic amines can undergo oxidative reactions. Secondary and tertiary amines, like those found in tricyclic antidepressants, can undergo N-dealkylation, a process that involves the oxidation of the alkyl group. In addition, oxidative...


