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在选择性检测糖类化合物的立体化学和区域化学趋势

Shan Jiang1, Jorge O Escobedo, Kyu Kwang Kim

  • 1Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, USA.

Journal of the American Chemical Society
|September 14, 2006
PubMed
概括

这项研究详细介绍了糖异构体如何与酸化学传感器相互作用,以信号特定的糖类. 研究人员开发了一种选择性化学传感器,用于核糖和相关化合物,从而实现可预测的色度和光反应.

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Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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