血低于0.48微摩尔/升 (10微克/分升) 和美国成年人死亡率
Andy Menke1, Paul Muntner, Vecihi Batuman
1Department of Epidemiology, Tulane University SPHTM, 1430 Tulane Ave, New Orleans, LA 70112, USA.
Circulation
|September 20, 2006
概括
即使血中含量很低,也与所有死因和心血管疾病的死亡风险更高有关. 这项研究强调环境暴露是对心血管死亡的重大公共卫生问题.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 流行病学 流行病学
背景情况:
- 血含量高于0.48微摩尔/升是已知的死亡风险因素.
- 之前的研究集中在更高的BLL上,使得较低水平的影响变得不太清楚.
研究的目的:
- 调查0.48微摩尔/升以下的BLL与美国普通人口的死亡率之间的联系.
- 为了确定较低水平的暴露是否对健康构成重大风险.
主要方法:
- 分析了来自第三次国家健康和营养检查调查 (1988-1994) 的13,946名成年人的全国代表性样本.
- 随访时间长达12年,以追踪所有原因和特定原因死亡率.
- 对混因素的多变量统计调整.
主要成果:
- 在较高的BLLs (≥0.17微摩尔/升) 和增加全因死亡率 (HR 1.25,P=0.002) 之间发现了显著的关联.
- 心血管死亡风险与较高的BLLs显著增加 (HR1.55,P=0.003),在>0.10微摩尔/升的水平上明显存在关联.
- 在这个范围内的BLL和癌症死亡率之间没有发现显著的联系.
结论:
- 这项研究表明,增加全因和心血管死亡率与比以前认可的更低的BLL相关.
- 环境暴露仍然是一个关键的公共卫生问题,显著影响心血管死亡率.
- 公共卫生战略应应对甚至较低水平的暴露,以减轻死亡风险.
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