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基因疗法:IL2RG在T细胞发育中的致癌性作用?

Karin Pike-Overzet1, Dick de Ridder, Floor Weerkamp

  • 1Department of Immunology, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands.

Nature
|September 22, 2006
PubMed
概括

与X相关的重症综合免疫缺陷 (X-SCID) 的介乐金-2受体马链 (IL2RG) 基因疗法可能不会直接致癌. 相反,恢复的信号允许T细胞发育,使LMO2等瘤基因能够促进白血病.

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