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相关概念视频

Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
CRISPR01:59

CRISPR

Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced Short...
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be inserted. The...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:

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相关实验视频

Updated: Jul 18, 2026

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

艾滋病治疗的分子标

H Mitsuya1, R Yarchoan, S Broder

  • 1National Cancer Institute, National Institutes of Health, Bethesda, MD 20892.

Science (New York, N.Y.)
|September 28, 1990
PubMed
概括

抗逆转录病毒疗法,包括类似于AZT的核类药物,可以抑制HIV复制. 未来的艾滋病治疗可能会专注于非核化物药物,以打击艾滋病毒的发病率和死亡率.

科学领域:

  • 病毒学 病毒学
  • 药理学 药理学是指药理学的学科.
  • 免疫学 免疫学 免疫学

背景情况:

  • 在人类免疫缺陷病毒 (HIV) 发现后,获得性免疫缺陷综合征 (AIDS) 研究加剧.
  • 抗逆转录病毒疗法旨在通过各种药物类别抑制HIV复制.
  • 核酸类类似物,如3'-Azido-2',3'-dideoxythymidine (AZT),是抑制HIV逆转录酶的关键.

研究的目的:

  • 审查艾滋病抗逆转录病毒治疗的发展.
  • 突出核酸类类似物在艾滋病毒治疗中的作用.
  • 讨论艾滋病实验治疗的未来方向.

主要方法:

  • 对抗逆转录病毒药物和艾滋病毒复制的现有文献的审查.
  • 对核糖类同类物的结构-活性关系的分析.
  • 在HIV复制周期中探索潜在的治疗点.

主要成果:

  • 广泛的药物抑制HIV复制在体外.
  • 核糖类类似物需要酸化以抑制逆转录酶.
  • AZT是第一个在艾滋病患者中测试的二氧核酸,产生了重要的结构活性数据.

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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
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Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

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Last Updated: Jul 18, 2026

Molecular Evolution of the Tre Recombinase
12:02

Molecular Evolution of the Tre Recombinase

Published on: May 29, 2008

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers
10:28

Repressing Gene Transcription by Redirecting Cellular Machinery with Chemical Epigenetic Modifiers

Published on: September 20, 2018

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10:50

Molecular Modulation by Lentivirus-Delivered Specific shRNAs in Endoplasmic Reticulum Stressed Neurons

Published on: April 24, 2021

结论:

  • 艾滋病毒复制为治疗干预提供了多个目标.
  • 预计非核类药物将在未来的艾滋病治疗中发挥更大的作用.
  • 抗逆转录病毒疗法将显著影响与艾滋病毒相关的疾病和死亡.