Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Differential Response to Heart Rate Reduction by Carvedilol in Heart Failure and Reduced Ejection Fraction Between Sinus Rhythm and Atrial Fibrillation　- Insight From J-CHF Study.

Circulation reports·2021
Same author

Correction: Optimization of Regularization Parameters in Compressed Sensing of Magnetic Resonance Angiography: Can Statistical Image Metrics Mimic Radiologists' Perception?

PloS one·2018
Same author

Kinematic Magnetic Resonance Imaging of the Thorax Using 2-Dimensional Balanced Subsecond Steady-state Free Precession Sequence During Forced Breathing in Comparison With Spirometry.

Journal of thoracic imaging·2018
Same author

Erratum to 'Improvement of intestinal absorption of curcumin by cyclodextrins and the mechanisms underlying absorption enhancement' [Int. J. Pharm. 2018, 535, 340-349].

International journal of pharmaceutics·2018
Same author

Role of transient receptor potential melastatin 2 in surgical inflammation and dysmotility in a mouse model of postoperative ileus.

American journal of physiology. Gastrointestinal and liver physiology·2018
Same author

Colitis with wall thickening and edematous changes during oral administration of the powdered form of Qing-dai in patients with ulcerative colitis: a report of two cases.

Clinical journal of gastroenterology·2018

相关实验视频

Updated: Jul 18, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

在日本使用普拉瓦斯塔丁进行心血管疾病的初级预防 (MEGA研究):一个前性随机对照试验.

Haruo Nakamura1, Kikuo Arakawa, Hiroshige Itakura

  • 1Mitsukoshi Health and Welfare Foundation, Tokyo, Japan. nakamura@mhwf.or.jp

Lancet (London, England)
|October 3, 2006
PubMed
概括

低剂量普拉瓦斯塔丁在日本高胆固醇血症患者中显著降低了冠心病风险. 这项研究证实了日本的他类药物的有效性,类似于西方人口,用于预防心血管事件.

更多相关视频

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
07:49

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

Published on: July 21, 2023

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

相关实验视频

Last Updated: Jul 18, 2026

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000
07:46

Assessing Endothelial Vasodilator Function with the Endo-PAT 2000

Published on: October 15, 2010

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models
07:49

A Pacing-Controlled Procedure for the Assessment of Heart Rate-Dependent Diastolic Functions in Murine Heart Failure Models

Published on: July 21, 2023

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion
05:31

Murine Model of Thoracic Aortic Dissection Induced by Oral β-Aminopropionitrile and Subcutaneous Angiotensin II Infusion

Published on: May 16, 2025

科学领域:

  • 心血管医学 心血管医学
  • 药理学 药理学是指药理学的学科.
  • 公共卫生 公共卫生

背景情况:

  • 由于缺乏直接证据,日本的高胆固醇血症治疗受到阻碍.
  • 评估了将西方他类药物治疗数据推算到日本人口的情况.

研究的目的:

  • 在日本高胆固醇血症患者中评估普拉瓦斯塔丁的疗效.
  • 为了确定西方对他类药物的治疗指南是否适用于日本.

主要方法:

  • 这是一项前性,随机的,开放的,盲目的研究.
  • 包括没有先前冠状动脉心脏病或中风的高胆固醇患者.
  • 将患者分配到单独的饮食或饮食加每天10-20毫克普拉瓦斯塔丁.

主要成果:

  • 普拉瓦斯塔丁显著降低了总胆固醇 (11.5%) 和LDL胆固醇 (18.0%).
  • 冠状动脉心脏病事件在普拉瓦斯塔丁组显着较低 (66 vs 101事件).
  • 两组之间恶性瘤或严重不良事件没有显著差异.

结论:

  • 在日本,低剂量普拉瓦斯塔丁有效降低了冠状动脉心脏病的风险.
  • 结果与欧洲和美国的高剂量他类药物研究结果一致.
  • 支持在日本人口中使用他类药物治疗高胆固醇血症.