促进尿路结石通道的医疗疗:一个元分析
John M Hollingsworth1, Mary A M Rogers, Samuel R Kaufman
1Department of Urology, Ann Arbor Veterans Affairs Health Services Research & Development Center of Excellence, Ann Arbor, MI, USA.
Lancet (London, England)
|October 3, 2006
概括
像α阻塞剂和通道阻塞剂这样的医学疗法显著增加了尿路结石通道的速率. 对于许多患有结石的患者来说,这些治疗方法为手术提供了潜在的替代方案.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 对于尿路结石通道的医学疗法未得到充分利用.
- 有效的医学治疗可以扩大尿路结石的治疗选择.
- 这项研究评估了特定药物类别在石通道中的疗效.
研究的目的:
- 系统地审查针对尿路结石疾病的α阻断剂和通道阻断剂的随机对照试验 (RCT).
- 评估这些医学疗法的有效性,以促进石头通过.
主要方法:
- 搜索了主要的数据库 (MEDLINE,EMBASE,CINAHL) 和会议摘要,直到2005年7月.
- 包括使用α阻断剂或通道阻断剂用于尿路结石的RCT.
- 使用元分析,从九项试验 (693名患者) 的数据汇总.
主要成果:
- 阿尔法阻断剂和通道阻断剂增加了65%的石头通过 (RR 1.65).
- 特定的药物类别显示出显著的综合风险比率:α阻断剂 (1.54) 和管阻断剂与类固醇 (1.90).
- 需要治疗的数量为4,表明高效率.
结论:
- 使用α阻断剂或通道阻断剂的医疗治疗是促进尿路结石通道的可行选择.
- 这些疗法可以帮助患者避免手术干预.
- 建议进一步进行高质量的RCT来确认疗效.
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