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相关概念视频

Fluid Mosaic Model01:34

Fluid Mosaic Model

The fluid mosaic model was first proposed as a visual representation of research observations. The model comprises the composition and dynamics of membranes and serves as a foundation for future membrane-related studies. The model depicts the structure of the plasma membrane with a variety of components, which include phospholipids, proteins, and carbohydrates. These integral molecules are loosely bound, defining the cell’s border and providing fluidity for optimal function.LipidsThe most...
Molecular Models02:00

Molecular Models

Physical models representing molecular architectures of chemical compounds play essential roles in understanding chemistry. The use of molecular models makes it easier to visualize the structures and shapes of atoms and molecules.
Fluid Mosaic Model01:19

Fluid Mosaic Model

Scientists identified the plasma membrane in the 1890s and its principal chemical components (lipids and proteins) by 1915. The model for plasma membrane structure, proposed in 1935 by Hugh Davson and James Danielli, was the first model to be widely accepted in the scientific community. The model was based on the plasma membrane's "railroad track" appearance in early electron micrographs. Davson and Danielli theorized that the plasma membrane's structure resembled a sandwich with the analogy of...
Newman Projections02:06

Newman Projections

Different notations are used to represent the three-dimensional structure of molecules on two-dimensional surfaces. One of the most commonly used representations is the dash-wedge formula. The dashed wedges, solid wedges, and the plane lines indicate the groups situated behind the plane, coming out of the plane, and in the plane, respectively.
The organic molecules rotate across the single bonds leading to numerous temporary three-dimensional structures of varying energy known as conformers.
Micelles01:30

Micelles

Micelle formation is an intricate process that hinges on the properties of amphiphilic or amphipathic molecules and the conditions of the system in which they are found. Amphiphilic molecules, which have both hydrophilic (water-attracting) and hydrophobic (water-repelling) parts, play a critical role in this process.In aqueous environments, these molecules arrange themselves such that their hydrophilic heads are turned towards the water phase, while their hydrophobic tails are oriented away...

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相关实验视频

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Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid
10:25

Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid

Published on: December 20, 2016

在液体/固体界面上由腺-胺四重奏自组装的超分子纳米模式.

Wael Mamdouh1, Mingdong Dong, Sailong Xu

  • 1Interdisciplinary Nanoscience Center and Department of Physics and Astronomy, University of Aarhus, DK-8000 Aarhus C, Denmark.

Journal of the American Chemical Society
|October 5, 2006
PubMed
概括

研究人员使用腺素 (A) 和胆氨酸 (T) 基创建了有序的DNA纳米模式. 这些AT四重奏形成了新的纳米级表面架构,在药物设计中具有潜在的应用.

科学领域:

  • 超分子化学 超分子化学
  • 纳米技术 纳米技术
  • 生物物理学的生物物理.

背景情况:

  • 基因配对对是基因信息存储的基础.
  • 控制分子在接口上的自我组装对纳米技术至关重要.

研究的目的:

  • 在液体/固体界面上研究由腺素 (A) 和胆氨酸 (T) DNA 基形成的超分子结构.
  • 探索DNA基配对的潜力,以创建纳米级表面架构.

主要方法:

  • 扫描道显微镜 (STM) 用于分子结构的真实空间成像.
  • 基于自相一致的电荷密度功能紧固结合 (SCC-DFTB) 计算用于理论分析.

主要成果:

  • 通过混合A和T基形成的有序的超分子纳米模式的观察.
  • 在特定的摩尔比率下形成明显的循环结构,不同于个别的基础模式.
  • 基于A-T基配对的A-T-A-T四重奏的识别.

结论:

  • 可以利用DNA基配对来构建纳米级表面架构.
  • A-T-A-T四重奏为创造生物相容的图案表面提供了一个平台.

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  • 这些结构在诸如药物设计之类的应用中对宿主-客人复杂化具有前景.