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Updated: Jul 16, 2026

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
10:44

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs

Published on: May 15, 2019

在AB5亚酶细胞毒素中,它使细胞内膜网的伴侣BiP无活化

Adrienne W Paton1, Travis Beddoe, Cheleste M Thorpe

  • 1School of Molecular and Biomedical Science, University of Adelaide, South Australia 5005, Australia. adrienne.paton@adelaide.edu.au

Nature
|October 7, 2006
PubMed
概括

细菌毒素 - - 细菌毒素 - - 细菌细胞毒素 - - 通过裂解必不可少的内分泌网膜伴侣BiP/GRP78.8的细胞死亡来触发细胞死亡. 这种特殊的裂变破坏了正常的细胞功能,突出了细菌病变的新机制.

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