在艾森门格综合征中使用固酶-5抑制剂:一项初步观察性研究
Saibal Mukhopadhyay1, Manish Sharma, S Ramakrishnan
1Department of Cardiology, GB Pant Hospital, New Delhi, India 110 002. saibalmukhopadhyay@yahoo.com
Circulation
|October 13, 2006
概括
塔达拉菲尔显著降低了肺血管阻力,并在艾森门格综合征患者中改善了氧和. 这种固酶-5抑制剂证明了安全性和有效性,在12周内改善了功能类和运动能力.
科学领域:
- 心脏病学 心脏病学
- 肺部病理学 肺部病理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 固酶-5抑制剂 (PDE5i) 降低异常性肺动脉高血压中的肺血管抵抗.
- 艾森门格综合征与异常性肺动脉高血压具有相似的肺血管病理.
研究的目的:
- 评估tadalafil在艾森门格综合征患者的短期血液动力学,耐受性和12周疗效.
- 评估塔达拉菲尔对肺血管抵抗,全身氧和和功能状态的影响.
主要方法:
- 血液动力学评估在基线和一次性1毫克/千克的塔达拉菲尔剂量 (最大40毫克) 后90分钟.
- 每天服用塔达拉菲尔12周,并重复血液动力学评估.
- 系统氧和度,系统血管阻力,世界卫生组织功能类和6分钟步行距离的评估.
主要成果:
- 剂后立即 (P<0.005) 和12周后 (P=0.03) 肺血管阻力平均值显著降低.
- 81.25%的患者是响应者,肺血管阻力下降≥20%.
- 改善了全身氧和 (P<0.005),WHO功能类 (P<0.0001) 和6分钟的步行距离 (P<0.001),没有任何不良影响.
结论:
- 塔达拉菲尔在选择的艾森门格综合征患者中展示了初步的疗效和安全性.
- 这些发现支持在这个患者小组中进一步调查tadalafil.
- 塔达拉菲尔改善了艾森门格综合征中的血液动力学,功能能力和氧化.
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