三氧化物的脂质封装减轻了细胞毒性,并允许控制抗癌药物释放
Haimei Chen1, Robert C MacDonald, Shuyou Li
1Department of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Journal of the American Chemical Society
|October 13, 2006
概括
新的脂质体封装三氧化物 (ATO) 显示了癌症治疗的降低毒性和受控释放. 这种纳米技术提高了ATO的风险/益处比率,扩大了其在瘤学中的潜在用途.
科学领域:
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
- 在瘤学瘤学.
背景情况:
- 三氧化物 (ATO) 是有效的急性肌肉细胞白血病和多发性骨髓瘤,但受限于毒性.
- 在其他癌症中扩大ATO的实用性需要管理其剂量依赖性毒性.
研究的目的:
- 开发一种新型的三氧化 (三氧化) 脂质体配方,可提高生物利用性和降低细胞毒性.
- 研究pH触发释放机制和封装药物的受控输送.
主要方法:
- 药物被装入100纳米脂质体中的高度 (>270mM).
- 描述包括ICP-OES,TEM和EDX来评估负载和稳定性.
- 在人体淋巴瘤细胞上进行了体外细胞毒性测试.
主要成果:
- 脂质体ATO在生理条件下表现出良好的保留 (>6个月) 和稳定性.
- 该配方在酸性环境中表现出pH触发的释放,模仿内分泌体.
- 与自由ATO相比,封装ATO显示出明显减弱对淋巴瘤细胞的细胞毒性.
结论:
- 脂质体封装提供了一种可行的策略,以控制的药物释放并减轻毒性.
- 这种方法提高了ATO的治疗指数,表明了更广泛的癌症治疗应用的潜力.
相关概念视频
02:49Cancer Therapies
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...