患有牛皮的患者心肌梗塞的风险
Joel M Gelfand1, Andrea L Neimann, Daniel B Shin
1Department of Dermatology and Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania, Philadelphia, PA 19104, USA. joel.gelfand@uphs.upenn.edu
JAMA
|October 13, 2006
概括
牛皮是心肌梗塞 (MI) 的独立风险因素. 患有严重牛皮的年轻患者面临心脏病发作的最高风险,这凸显了这种T辅助细胞1型疾病对心血管的影响.
科学领域:
- 免疫皮肤学 免疫皮肤学
- 心血管流行病学心血管流行病学
- 公共卫生 公共卫生
背景情况:
- 牛皮是一种T-辅助细胞1型 (T(H) 1) 免疫性疾病,已与心血管问题有关.
- 之前关于牛皮和心血管疾病的研究是基于医院的,缺乏对主要风险因素的控制.
研究的目的:
- 在基于人口的队列中,调查牛皮是否是心肌梗塞 (MI) 的独立风险因素.
- 评估牛皮病严重程度和心脏病发作风险之间的关联,同时控制心血管风险因素.
主要方法:
- 在英国 (1987-2002) 进行了一项基于人口的前性队列研究,涉及超过556,000人.
- 轻度/重度牛皮患者与对照患者的MI发病率比较,调整为高血压,糖尿病,高脂血症,年龄,性别,吸烟和BMI.
- 根据系统治疗的使用,根据牛皮的严重程度进行分类;平均随访时间为5.4年.
主要成果:
- 牛皮患者显示心肌梗塞的调整相对风险 (RR) 增加.
- 对于一个30岁的人来说,心脏病发作的RR是1.29 (轻度牛皮) 和3.10 (严重牛皮).
- 对于一个60岁的老人来说,MI的RR是1.08 (轻度牛皮) 和1.36 (严重牛皮).
结论:
- 牛皮似乎是心肌梗塞 (MI) 的独立风险因素.
- 与牛皮相关的MI的相对风险在年轻人中显着更高,特别是那些患有严重疾病的人.
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