补剂C3b的结构为补剂激活和调节提供了洞察力
A Abdul Ajees1, K Gunasekaran, John E Volanakis
1Center for Biophysical Sciences and Engineering, 1530 3rd Avenue South, Birmingham, Alabama 35294, USA.
Nature
|October 20, 2006
概括
补充系统是补充系统.
科学领域:
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
- 结构生物学 结构生物学
背景情况:
- 人体补充系统对于天生的免疫力至关重要,有助于消除病原体.
- 不调节的补充激活有助于炎症和自身免疫性疾病.
- 补充成分3 (C3) 是补充激活的核心,产生C3b.
研究的目的:
- 阐明补充成分3b (C3b) 的分子结构.
- 了解C3b在补充级联中的激活和功能的结构基础.
- 揭示C3b的结构如何促进与调节蛋白和点表面的相互作用.
主要方法:
- 使用X射线结晶学来确定C3b.的结构.
- 进行了对C3,C3c和C3b的比较结构分析.
- 采用了分子建模和对形状变化的分析.
主要成果:
- 在CUB域中,C3b结构显示出显著的二次结构损失.
- 这种结构变化重新定位了硫域,使得形状变化成为可能.
- 改变的结构提高了连接物结合部位的可访问性,并创建了一个空腔屏蔽因子I裂部位.
结论:
- 确定的C3b结构为其激活和功能提供了分子基础.
- 结构洞察力解释了C3b如何共地附着在表面上,并与调节因素相互作用.
- 这项工作促进了对补充系统调节及其在疾病中的作用的理解.
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Antibodies consist of four polypeptide chains: two identical heavy...
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Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
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Antibodies consist of four polypeptide chains: two identical heavy...
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