在接受皮肤冠状动脉干预治疗的急性冠状动脉综合征患者中,abciximab的年龄依赖作用
Gjin Ndrepepa1, Adnan Kastrati, Julinda Mehilli
1Deutsches Herzzentrum, Technische Universität, Lazarettstrasse 36, 80636 München, Germany.
Circulation
|October 25, 2006
概括
阿布西西马布对年轻的非ST升高急性冠状动脉综合征患者提供更大的益处,这些患者正在接受皮肤冠状动脉干预 (PCI). 老年患者在使用abciximab时,主要心脏不良事件 (MACE) 没有显著差异.
科学领域:
- 心脏病学 心脏病学
- 干预心脏病学 干预心脏病学
- 老年心脏病学 老年心脏病学
背景情况:
- 在接受PCI的非ST升高急性冠状动脉综合征 (NSTE-ACS) 中,对abciximab的基于年龄的有效性数据有限.
- 需要评估abciximab在PCI治疗的ACS患者的年龄相关临床益处.
研究的目的:
- 为了确定abciximab在接受PCI的NSTE-ACS患者的疗效是否因年龄而异.
- 分析与abciximab进行PCI后主要心脏不良事件 (MACE) 的年龄相关差异.
主要方法:
- 从ISAR-REACT 2研究中随机获得abciximab或安慰剂的2022年NSTE-ACS患者的回顾性分析.
- 根据逻辑回归和引导重新抽样,患者分为年轻人 (<70岁) 和老年人 (≥70岁) 的分层.
- 主要终点:PCI后MACE的30天发病率.
主要成果:
- 接受abciximab的年轻患者 (70岁以下) 与安慰剂 (13.3%;RR0.57,P=0.001) 相比,MACE显著降低 (7.7%).
- 老年患者 (≥70岁) 在abciximab (10.9%) 和安慰剂 (9.9%;RR 1.10,P=0.65) 之间MACE没有显著差异.
- 年龄和abciximab在MACE降低功效之间的显著相互作用 (P=0.04),年轻人受益更大.
结论:
- 在接受PCI的NSTE-ACS患者中,abciximab的疗效取决于年龄.
- 年轻的患者 (70岁以下) 与老年患者相比,从abciximab获得的临床益处更大.
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